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Indian J Exp Biol ; 1989 Dec; 27(12): 1087-9
Article in English | IMSEAR | ID: sea-56522

ABSTRACT

Effect of oral administration of gossypol acetic acid (15 mg/kg/day) for 10 weeks, on certain enzymes, which may be taken as markers for the different stages of spermatogenesis, was studied in male albino rats. Gossypol produced a significant decrease in hyaluronidase and sorbitol dehydrogenase, while no change was observed in beta-glucuronidase and acid phosphatase. A significant increase in the total lactate dehydrogenase activity was observed in the testis. The possible significance of these findings is discussed.


Subject(s)
Animals , Glucuronidase/metabolism , Gossypol/pharmacology , Hyaluronoglucosaminidase/metabolism , L-Iditol 2-Dehydrogenase/metabolism , L-Lactate Dehydrogenase/metabolism , Male , Rats , Rats, Inbred Strains , Spermatogenesis/drug effects , Testis/drug effects
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